Amistrs are terrible. Always. They are outperformed in every situation by at least one other homunculus. My old vanilmirth could flee tank any low end MVPs (and could even flee tank through Dracula's Hell's Judgment). My current Lif is fairly tanky and can out DPS Amistr by the thousands. I've never used a Filir but since (if their +flee skill is fixed yet) they can achieve insane flee I'd imagine it wins versus Amistr for "tanking" as well.