Dead Space 2

[Galt]

Taking place 3 years after the first Dead Space, main character Isaac Clarke has made his way off the Necromorph-infested Ishimura, traveling around and eventually making his way to the space station Sprawl. The setting of the game has changed from the dark, dank, and eerie corridors of the Ishimura to the brightly-colored and expansive hallways of Sprawl.

Isaac's not himself anymore since the Ishimura incident, and is (from the article) going through psychiatric treatment in the hospital onboard the Sprawl, but when the Necromorphs appear, it's up to Isaac (again) to put the stinking Necromophs in their place... one curb stomp at a time. Expect brand-new and specialized weapons, new, intelligent enemies, and another crap-your-pants story with all the goodies of horror involved.

This time around, he's got a personality, and will talk, and the Ishimura from the first game will make another appearance in Sprawl... though whether its a good or bad thing, remains to be seen (supposed images indicate a ship looking like the Ishimura is docked with the space station).

Dead Space 2 - Game Informer High Quality Scans
Read that for all the juicy bits.

[Sepharius]

I call the line gun.